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Index > Protein center > Mcl1(Gene name) > Mouse
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  • Mcl1 (Gene name),
  • Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Protein name ),  MCL1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Mcl1;
    Protein name:
    Induced myeloid leukemia cell differentiation protein Mcl-1 homolog;
    Alternative:
    Bcl-2-related protein EAT/mcl1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with BAD, BOK, BIK, BAX, BAK1, and TPT1 (By similarity). Interacts with BBC3, BCL2L11, BFM and PMAIP1.
    Function:
    Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
    Subcellular Location:
    Membrane Single-pass membrane protein Cytoplasm Mitochondrion Nucleus nucleoplasm Cytoplasmic, associated with mitochondria.
    Protein Attributes:
    Sequence length:
    331
    Sequence:
    50:
    MFGLRRNAVI | GLNLYCGGAS | LGAGGGSPAG | ARLVAEEAKA | RREGGGEAAL | 
    100:
    LPGARVVARP | PPVGAEDPDV | TASAERRLHK | SPGLLAVPPE | EMAASAAAAI | 
    150:
    VSPEEELDGC | EPEAIGKRPA | VLPLLERVSE | AAKSSGADGS | LPSTPPPPEE | 
    200:
    EEDDLYRQSL | EIISRYLREQ | ATGSKDSKPL | GEAGAAGRRA | LETLRRVGDG | 
    250:
    VQRNHETAFQ | GMLRKLDIKN | EGDVKSFSRV | MVHVFKDGVT | NWGRIVTLIS | 
    300:
    FGAFVAKHLK | SVNQESFIEP | LAETITDVLV | RTKRDWLVKQ | RGWDGFVEFF | 
    331:
    HVQDLEGGIR | NVLLAFAGVA | GVGAGLAYLI | R
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    KEGG:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Cat.:
    E2097h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Cat.:
    E2097m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Cat.:
    E2097d
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Cat.:
    E2097r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Cat.:
    U2097r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Cat.:
    U2097d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Cat.:
    U2097m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Cat.:
    U2097h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Cat.:
    P2097Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Polyclonal Antibody for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Cat.:
    P2097Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Cat.:
    P2097Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Monoclonal Antibody for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Monoclonal Antibody for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Monoclonal Antibody for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Protein for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Protein for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Protein for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
    Protein for Mouse Induced myeloid leukemia cell differentiation protein Mcl-1 homolog

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Up-regulated expression of murine Mcl1/EAT, a bcl-2 related gene, in the early stage of differentiation of murine embryonal carcinoma cells and embryonic stem cells."
      Okita H. , Umezawa A. , Suzuki A. , Hata J.
      Biochim. Biophys. Acta1398:335-341(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION
      tissue: Fetus.
    2. 2.
      "MCL-1V, a novel mouse antiapoptotic MCL-1 variant, generated by RNA splicing at a non-canonical splicing pair."
      Kojima S. , Hyakutake A. , Koshikawa N. , Nakagawara A. , Takenaga K.
      Biochem. Biophys. Res. Commun.391:492-497(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;SUBCELLULAR LOCALIZATION
      strain: C57BL/6.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Embryonic stem cell.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: Czech II.
      strain: FVB/N.
      tissue: Mammary tumor.
      tissue: Salivary gland.
    6. 6.
      "Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response."
      Chao J.-R. , Wang J.-M. , Lee S.-F. , Peng H.-W. , Lin Y.-H. , Chou C.-H. , Li J.-C. , Huang H.-M. , Chou C.-K. , Kuo M.-L. , Yen J.J.-Y. , Yang-Yen H.-F.
      Mol. Cell. Biol.18:4883-4898(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-65;INDUCTION
      strain: 129/SvJ.
    7. 7.
      "Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1."
      Maurer U. , Charvet C. , Wagman A.S. , Dejardin E. , Green D.R.
      Mol. Cell21:749-760(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS INHIBITOR OF APOPTOSIS;PHOSPHORYLATION AT SER-140 BY GSK3-ALPHA AND GSK3-BETA;INTERACTION WITH BCL2L11
    8. 8.
      "Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands."
      Day C.L. , Chen L. , Richardson S.J. , Harrison P.J. , Huang D.C.S. , Hinds M.G.
      J. Biol. Chem.280:4738-4744(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 152-308;INTERACTION WITH BCL2L11; BMF AND PMAIP
    9. 9.
      "Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1."
      Day C.L. , Smits C. , Fan F.C. , Lee E.F. , Fairlie W.D. , Hinds M.G.
      J. Mol. Biol.380:958-971(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 148-308 IN COMPLEXES WITH WITH BBC3 AND PMAIP1
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